The Carolina Panthers take on the San Francisco 49ers in NFL Football action on Monday, November 24, 2025. Kickoff is set for 8:15 PM ET.

Need betting advice for this game? You’ve found the right article! We at CapperTek have all the latest sports betting tools and information to help put you on the winning side of the betting action for this match-up.

Panthers vs. 49ers Game Details and Betting Odds

Away Team: Carolina Panthers (Underdog)
Home Team: San Francisco 49ers (Favorite)
Date: Monday, November 24, 2025
Time: 8:15 PM ET
League: National Football League (NFL)

Carolina Panthers Moneyline: +262
San Francisco 49ers Moneyline: -317

Carolina Panthers Spread: +6.5 (+100)
San Francisco 49ers Spread: -6.5 (-115)

Game Total Points: 47.5 (Over -119 / Under +102)

Betting odds provided by Premium Picks. Visit PremiumPicks.com today and check out their unique wagering system that will help you beat the books! Odds and lines are the best available at the time of publishing and are subject to change.

A Deeper Look Inside the Betting Numbers

We here at CapperTek provide in-depth betting trends for both the Carolina Panthers and the San Francisco 49ers, but let’s take a deeper look inside some of the betting numbers for this match-up right now.

First let’s take a glance at the away team and +262 betting underdogs, the Carolina Panthers.

In their last 10 games, the Panthers have a Straight Up record of 6 wins, 4 losses and an active Straight Up streak of 1 win in a row. Also in their last 10 games, the Panthers have an Against-the-Spread record of 7 wins, 3 losses and an active Against-the-Spread streak of 1 win in a row. The Game Total Points results for Panthers games have a record of 6 overs, 4 unders in their last 10 games with an active streak of 1 over in a row.

OK now let’s take a glance at the home team and -317 betting favorites, the San Francisco 49ers.

In their last 10 games, the 49ers have a Straight Up record of 6 wins, 4 losses and an active Straight Up streak of 1 win in a row. Also in their last 10 games, the 49ers have an Against-the-Spread record of 5 wins, 5 losses and an active Against-the-Spread streak of 1 win in a row. The Game Total Points results for 49ers games have a record of 7 overs, 2 unders, 1 push in their last 10 games with an active streak of 3 overs in a row.

If you want more detailed betting information for this match-up such as the trends or steaks broken down into Home vs. Away splits, or Favorite vs. Underdog splits, make sure to check out the Panthers vs. 49ers Trend Finder directly.

Who’s Going to Win This Game? Our Prediction

We pride ourselves here at CapperTek on providing our users with the most advanced machine learning artificial intelligence to simulate game outcomes using algorithms we have custom designed over 10+ years of research and development.

Based on our simulation of the Panthers vs. 49ers NFL game, we have the San Francisco 49ers beating the Carolina Panthers with a simulated final score of: Carolina Panthers [21] – San Francisco 49ers [35]

Sometimes our game simulations change, like if there’s a major line movement, drastic shift in the odds, or if there’s a key injury, etc. To make sure you have the latest and most accurate simulation, you can run the Panthers vs. 49ers Simulation directly. Also after the Panthers vs. 49ers game is finished, you can re-run the simulation and check out how the simulated final result did compared to the actual final result.

What Should I Bet On? Our Free Picks

Well let’s get down to the real reason you’re here, who or what should you bet on in the Panthers vs. 49ers NFL match-up? Based on the simulated prediction and results for this match-up above, we here at CapperTek suggest you make the following bets:

Free Moneyline Pick: 49ers -317

Free Spread Pick: 49ers -6.5 (-115)

Free Total Pick: Over 47.5 (-119)

Hopefully our free picks and predictions help you out if you’re wagering on the Carolina Panthers vs. San Francisco 49ers NFL Football match-up. Our betting tips are based on detailed analytics and wagering intelligence to provide you the best possible plays. Our goal is to provide valuable sports betting information to gamblers and help put them on the right side of the action.

Please remember to always wager responsibly. For problem gambling help, please visit the National Council on Problem Gambling.

This article was generated using CapperTek’s Betelligence Publisher API. Learn more.

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• Source: https://www.cappertek.com/article.asp?a=panthers-vs-49ers-betting-odds-free-picks-and-predictions-11-24-2025-391757