The Detroit Lions will visit the Kansas City Chiefs on Sunday Night Football in Week 6 of the NFL season. The Lions haven’t lost since dropping their opener in Week 1. They will look to keep their winning streak alive against a Chiefs team that is struggling to live up to expectations thus far. Before kickoff from Kansas City on Sunday night, continue reading to get my Lions vs Chiefs prediction for this matchup.
Our Lions vs Chiefs Pick
- Pick: Lions Moneyline
- Confidence: ★★★★☆
Game Snapshot
- Matchup: Detroit Lions at Kansas City Chiefs
- Date & Time: Sunday, October 12, 2025, 8:20 PM ET
- Venue: GEHA Field at Arrowhead Stadium, Kansas City, MO
- Broadcast: NBC
Lions vs Chiefs Odds
| Spread | Moneyline | Total |
|---|---|---|
| Chiefs -1.5 | Chiefs -115 / Lions -105 | 50.5 |
Key Storylines
- Injury hits in Detroit’s secondary: Lions cornerback Terrion Arnold will miss extended time with a shoulder injury, further weakening a unit already impacted by D.J. Reed landing on IR. This raises concerns about Detroit’s ability to slow down big plays.
- Kansas City’s offense under pressure: Kansas City dropped a 31–28 game to Jacksonville after a late-game collapse. Patrick Mahomes threw a 99-yard pick-six that swung momentum in Jacksonville’s favor. The Chiefs have struggled with consistency and cannot afford more miscues.
- New weapons emerging for KC: Rookie Brashard Smith is seeing increased involvement as a dual-threat back/receiver. With the Chiefs seeking more balance beyond Mahomes and Travis Kelce having to do it all, Smith’s play could be important to this game’s outcome.
Quarterback Play
Jared Goff has been methodical and efficient through five games, throwing 12 touchdown passes to just two interceptions. He’s not the most electric passer but does plenty to keep the Lions’ offense in rhythm. Kansas City’s Patrick Mahomes is still the engine of the Chiefs’ offense. Even in the Jacksonville loss, he piled up 318 passing yards and a touchdown, though the interception return proved costly. He can win in multiple ways, and when things break down, he’s capable of improvising.
Betting Trends & H2H
- Detroit is 4-1 against the spread this season. They enter this game tied for the best ATS record in the NFL.
- Kansas City is 2-3 against the spread going into Week 6.
- Both teams are 3-2 in the over/under market after their first five games.
Lions vs Chiefs Model Projection
Score Projection: Detroit 27 – Kansas City 21
Win Probability: Detroit 52%, Kansas City 48%
Final Thoughts
The Lions looked bad in their first game of the season against the Green Bay Packers. But since they lost that rivalry game on the road, they haven’t been in a game decided by seven points or fewer. Detroit should continue its winning ways in this contest against a Chiefs team whose best win this season is against a Ravens team that is in the process of falling apart. I’ll lay the points with Detroit in one of the marquee matchups of the NFL Week 6 slate.
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- Source: https://ats.io/nfl/detroit-lions-vs-kansas-city-chiefs-prediction-10-12-2025/470120/
